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Updated: Jun 1, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
3-[(E)-2-(5,7-Dichloro-8-hydroxy-quinolin-2-yl)vin-yl]-4-hydroxy-phenyl acetate
Summary
This study details the crystal structure of a dichloro-nitro-quinoline derivative. Molecules form a 1D polymer via intermolecular hydrogen bonds, with intramolecular bonds also observed within the structure.
Area of Science:
- Crystallography
- Materials Science
- Organic Chemistry
Background:
- Understanding molecular conformation and intermolecular interactions is crucial for predicting material properties.
- Crystal engineering relies on identifying and controlling hydrogen bonding networks.
Purpose of the Study:
- To elucidate the crystal structure and hydrogen bonding patterns of a novel C(19)H(13)Cl(2)NO(4) compound.
- To investigate the conformational preferences and intermolecular assembly of the title molecule.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding interactions, including intramolecular and intermolecular types, was performed.
Main Results:
- Two symmetry-independent molecules exhibit similar conformations, with a twisted acetyl group.
- Intramolecular O-H⋯N hydrogen bonds are present in the 8-hydroxy-quinoline residues.
- Intermolecular O-H⋯O hydrogen bonds lead to a one-dimensional polymeric structure along the a axis.
- Disordered hydroxyl hydrogen atoms were observed in O-H⋯O hydrogen bonds involving the 4-hydroxy-phenyl group.
Conclusions:
- The crystal structure reveals a unique one-dimensional polymeric assembly driven by specific hydrogen bonding motifs.
- Conformational flexibility and hydrogen bonding play key roles in the self-assembly of this organic compound.
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