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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-(2-Iodo-benzenesulfonamido)acetic acid
This study details the crystal structure of a halogenated sulfonamide, revealing intermolecular hydrogen bonds that form dimers. These dimers further assemble into a unique ribbon-like polymer structure in the solid state.
Area of Science:
- Medicinal chemistry
- Crystallography
- Organic chemistry
Background:
- Halogenated sulfonamides are a medicinally significant class of organic compounds.
- Understanding the crystal structure of such compounds is crucial for drug design and development.
Purpose of the Study:
- To elucidate the crystal structure of a specific halogenated sulfonamide (C(8)H(8)INO(4)S).
- To investigate the intermolecular interactions governing the compound's solid-state architecture.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding and other intermolecular forces was performed.
Main Results:
- The crystal structure features centrosymmetric dimers formed by intermolecular O-H⋯O hydrogen bonds between carboxylic acid groups.
- These dimers are further linked via centrosymmetric N-H⋯O interactions involving amido and sulfonyl groups.
- A ribbon-like polymer structure propagating along the b-axis was observed.
Conclusions:
- The study reveals a novel ribbon-like polymer structure for the investigated halogenated sulfonamide.
- The observed crystal packing is dictated by specific hydrogen bonding networks, offering insights into structure-property relationships.
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