Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
Structure and Nomenclature of Alcohols and Phenols02:23

Structure and Nomenclature of Alcohols and Phenols

Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
NMR Spectroscopy of Benzene Derivatives01:37

NMR Spectroscopy of Benzene Derivatives

Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling constants depend...
Hydrolysis of Chlorobenzene to Phenol: Dow Process01:10

Hydrolysis of Chlorobenzene to Phenol: Dow Process

Simple aryl halides do not react with nucleophiles under normal conditions. However, the reaction can proceed under drastic conditions involving high temperatures and high pressure to give the substituted products. For example, chlorobenzene is converted to phenol using aqueous sodium hydroxide at 350 °C under high pressure by the Dow process. The reaction follows an elimination-addition mechanism involving a benzyne intermediate. Here, the chloride ion is eliminated to generate the benzyne...
Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conjugation of Antibiotics to Peptidomimetics Enhances Antimicrobial Spectrum of Activity.

Antibiotics (Basel, Switzerland)·2026
Same author

Electronic coupling in a synthetic model of the Cu-cofactor unit of the P<sub>M</sub> state in cytochrome <i>c</i> oxidase.

Chemical communications (Cambridge, England)·2026
Same author

<i>N</i>-Arylsulfonamidocalix[4]arenes with narrow pH-responsive binding near neutral pH.

Chemical science·2025
Same author

Tuning the Structure-Functional Properties Within Peptide-Mimicking Antimicrobial Hydrogels.

Antibiotics (Basel, Switzerland)·2025
Same author

Antibacterial peptidomimetics based on guanidine-functionalized di-tertiary amides.

RSC medicinal chemistry·2025
Same author

Synthesis and biological evaluation of pyrano and furano fused ring isoflavene derivatives.

RSC advances·2025

Related Experiment Video

Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline.

Veshal Gopal, Mohan Bhadbhade, Daniel Shiu Hin Chan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    Researchers synthesized a novel quinolinone derivative, C(17)H(14)BrNO(2), using a Vilsmeier-type reaction. Structural analysis revealed distinct molecular arrangements and intermolecular interactions in its crystal form.

    More Related Videos

    Green Synthesis of Quinoline-Based Ionic Liquid
    05:59

    Green Synthesis of Quinoline-Based Ionic Liquid

    Published on: September 27, 2024

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Facile Preparation of 4-Substituted Quinazoline Derivatives
    11:51

    Facile Preparation of 4-Substituted Quinazoline Derivatives

    Published on: February 15, 2016

    Green Synthesis of Quinoline-Based Ionic Liquid
    05:59

    Green Synthesis of Quinoline-Based Ionic Liquid

    Published on: September 27, 2024

    Area of Science:

    • Organic Chemistry
    • Crystallography
    • Medicinal Chemistry

    Background:

    • Quinolinone derivatives are important scaffolds in medicinal chemistry.
    • Understanding the structure-activity relationship requires detailed crystallographic analysis.

    Purpose of the Study:

    • To synthesize and characterize a novel brominated quinolinone derivative.
    • To elucidate the crystal structure and intermolecular interactions of the synthesized compound.

    Main Methods:

    • Vilsmeier-type reaction for synthesis.
    • Single-crystal X-ray diffraction for structural determination.

    Main Results:

    • Successful synthesis of C(17)H(14)BrNO(2).
    • Two independent molecules in the asymmetric unit with differing phenyl ring orientations.
    • Formation of centrosymmetric tetrameric units via hydrogen bonding.
    • Crystal structure stabilized by C-H⋯π and C-Br⋯π interactions.

    Conclusions:

    • The study provides a detailed structural characterization of a novel brominated quinolinone.
    • The identified intermolecular interactions offer insights into crystal packing and potential solid-state properties.