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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Ethyl 2-(1,2,3,4-tetrahydro-spiro-[carba-zole-3,2'-[1,3]dioxolan]-9-yl)acetate
Philipp M G Löffler1, Trond Ulven, Andrew D Bond
1University of Southern Denmark, Department of Physics and Chemistry, Campusvej 55, 5230 Odense M, Denmark.
Abstract:
In the title compound, C(18)H(21)NO(4), the hydrogenated six-membered ring of the carbazole unit adopts a half-chair conformation. The dioxolane ring and ethyl-acetate substituent point to opposite sides of the carbazole plane. The ethyl-acetate substituent adopts an essentially fully extended conformation, and its mean plane forms a dihedral angle of 83.8 (1)° with respect to the carbazole mean plane. The mol-ecules are arranged into stacks in which the carbazole planes form a dihedral angle of 4.4 (1)° and have an approximate inter-planar separation of 3.6 Å.
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