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Updated: Jun 1, 2026
14:39
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
6,8-Dihydr-oxy-3-methyl-isocoumarin
Summary
A novel compound, C(10)H(8)O(4), was identified from the endophytic fungus Cephalo-sporium sp. Its crystal structure reveals molecules forming one-dimensional chains linked by hydrogen bonds and C-H interactions into 2D layers.
Area of Science:
- * Natural Product Chemistry
- * Crystallography
- * Mycology
Background:
- * Endophytic fungi are a rich source of novel bioactive compounds.
- * Understanding the structural and chemical properties of fungal metabolites is crucial for drug discovery.
Purpose of the Study:
- * To isolate and characterize a new compound from Cephalo-sporium sp.
- * To elucidate the crystal structure and intermolecular interactions of the isolated compound.
Main Methods:
- * Fermentation of endophytic fungus Cephalo-sporium sp.
- * Isolation and purification of the title compound (C(10)H(8)O(4)).
- * X-ray crystallography for crystal structure determination.
Main Results:
- * The title compound, C(10)H(8)O(4), was successfully isolated.
- * Crystal structure analysis revealed a one-dimensional chain formation via O-H⋯O hydrogen bonds.
- * Extended two-dimensional layers were formed through non-classical C-H⋯O interactions.
Conclusions:
- * The study reports a novel compound from an endophytic fungus.
- * The crystal structure provides insights into the self-assembly of molecules through specific intermolecular forces.
- * Findings contribute to the understanding of natural product structures and their solid-state arrangements.
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