4-Amino-pyridinium hydrogen succinate

Area of Science:

• Crystallography
• Supramolecular Chemistry
• Organic Chemistry

Background:

• 4-amino-pyridine is a key organic base with applications in synthesis.
• Hydrogen succinate is a common counterion used in salt formation.
• Understanding crystal packing is crucial for materials science and drug design.

Purpose of the Study:

• To characterize the crystal structure of the 4-amino-pyridine hydrogen succinate salt.
• To investigate the protonation site and hydrogen bonding network within the crystal lattice.
• To analyze the intermolecular interactions governing crystal packing.

Main Methods:

• Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
• Analysis of bond lengths, bond angles, and intermolecular contacts was performed.
• Hydrogen bonding and other non-covalent interactions were identified and characterized.

Main Results:

• The asymmetric unit contains a 4-amino-pyridinium cation and a hydrogen succinate anion.
• Protonation occurred at the aromatic nitrogen atom of the 4-amino-pyridine molecule.
• Intermolecular hydrogen bonds (O-H⋯O and N-H⋯O) stabilize a two-dimensional array, with short C-H⋯O contacts also observed.

Conclusions:

• The crystal structure of 4-amino-pyridine hydrogen succinate is elucidated.
• The study confirms protonation of the pyridine ring and highlights the role of hydrogen bonding in crystal assembly.
• The observed packing motif provides insights into the solid-state behavior of related organic salts.