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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Ethyl 6-methyl-sulfanyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-carboxyl-ate monohydrate
Teng-Fei Shao1, Gui-Long Zhao, Jian-Wu Wang
1School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.
Abstract:
The title compound, C(15)H(15)N(3)O(2)S·H(2)O, has been obtained in a search for new imidazo[1,2-b]pyrazole derivatives with better biological activity. The 1H-imidazo[1,2-b]pyrazole plane forms a dihedral angle of 16.90 (3)° with the benzene ring. π-π inter-actions are indicated by the short distance of 3.643 (2) Å between the centroids of the benzene and imidazole rings. The crystal structure also involves inter-molecular O-H⋯N hydrogen bonds.
