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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-[2-Hydr-oxy-4-(pyrrolidin-1-yl)benzo-yl]benzoic acid
1School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.
Abstract:
The title compound, C(18)H(17)NO(4), crystallizes with two indepen-dent mol-ecules in the asymmetric unit. The pyrrolidine ring in one mol-ecule is disordered over two positions, with refined site-occupancy factors of 0.853 (5) and 0.147 (5). The dihedral angles between the planes of the benzene rings in the two independent mol-ecules are 56.8 (2) and 68.2 (5)°. The mol-ecular conformations are stabilized by intra-molecular O-H⋯O hydrogen bonds. In the crystal structure, mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds, forming dimers and generating rings of graph-set motif R(2) (2)(8).
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