Related Experiment Video
Updated: Jun 1, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Isoamyl 2-(5-bromo-3-methyl-sulfin-yl-1-benzofuran-2--yl)acetate
Abstract:
In the title compound, C(16)H(19)BrO(4)S, the O atom and the methyl group of the methyl-sulfinyl substituent lie on opposite sides of the plane of the benzofuran fragment. The crystal structure exhibits aromatic π-π inter-actions between the benzene rings of adjacent mol-ecules [centroid-centroid distance = 3.643 (2) Å] and nonclassical C-H⋯O hydrogen bonds.
Related Concept Videos
Preparation and Reactions of Sulfides
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Alkyl Halides
Alkyl halides are halogen-substituted alkanes wherein one or more hydrogen atoms of an alkane is replaced by a halogen atom such as fluorine, chlorine, bromine, or iodine. The carbon atom in an alkyl halide is bonded to the halogen atom, which is sp3-hybridized and exhibits a tetrahedral shape.
Unlike alkyl halides, compounds in which a halogen atom is bonded to an sp2 -hybridized carbon atom of a carbon-carbon double bond (C=C) are called vinyl halides. Whereas aryl...
Nucleophilic Aromatic Substitution: Elimination–Addition

