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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

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Published on: May 27, 2015

5-Bromo-1-methyl-indolin-2-one.

Mao-Sen Yuan¹, Qi Shuai, Lin Wang

¹College of Science, Northwest A&F University, Yangling 712100, Shanxi Province, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This summary is machine-generated.

This study examines the molecular structure of C(9)H(8)BrNO, revealing a near-planar conformation. The research highlights significant pi-electron delocalization within the molecule, particularly involving the N-C=O group.

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Published on: January 21, 2020

Area of Science:

Organic Chemistry
Crystallography

Background:

Understanding the three-dimensional structure and electronic properties of organic molecules is crucial in drug design and materials science.
Indoline derivatives are important scaffolds in medicinal chemistry.

Purpose of the Study:

To determine the precise molecular conformation and electronic delocalization in the title compound, C(9)H(8)BrNO.
To investigate the extent of pi-electron delocalization within the indoline system.

Main Methods:

Single-crystal X-ray diffraction was employed to analyze the molecular structure.
Computational methods were used to assess pi-electron delocalization.

Main Results:

The title molecule, C(9)H(8)BrNO, exhibits a nearly planar conformation.
The inter-planar angle between the benzene and five-membered rings is 1.38(1)°.
Pi-electron delocalization is more pronounced in the N-C=O group compared to the N-C-C(benzene) linkage.

Conclusions:

The structural and electronic properties of C(9)H(8)BrNO suggest potential for further functionalization and application.
The observed pi-delocalization influences the molecule's reactivity and potential interactions.