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Related Concept Videos

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic Acid Derivatives: Overview01:15

Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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N-(3,4-Diethoxy-phen-yl)acetamide.

Pei-Hua Ma1, Kai-Zhi Zhou, Mei-Lian Sun

  • 1Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary
This summary is machine-generated.

The crystal structure of C(12)H(17)NO(3) reveals anti conformations of N-H and C=O bonds. Hydrogen bonds play a key role in the compound's crystal packing.

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Area of Science:

  • Crystallography
  • Chemical Physics
  • Molecular Structure

Background:

  • Understanding molecular conformations is crucial in chemistry.
  • Crystal packing influences material properties.
  • Hydrogen bonding is a fundamental intermolecular force.

Purpose of the Study:

  • To determine the crystal structure of the title compound C(12)H(17)NO(3).
  • To analyze the conformational aspects of the N-H and C=O bonds.
  • To investigate the role of hydrogen bonding in crystal packing.

Main Methods:

  • Single-crystal X-ray diffraction was employed to elucidate the crystal structure.
  • Conformational analysis was performed on the determined molecular geometry.
  • Intermolecular interactions, specifically hydrogen bonds, were identified and characterized.

Main Results:

  • The crystal structure of C(12)H(17)NO(3) was successfully determined.
  • The N-H and C=O bonds were found to adopt an anti conformation.
  • N-H⋯O hydrogen bonds were identified as significant in stabilizing the crystal lattice.

Conclusions:

  • The anti conformation of the N-H and C=O bonds is a key feature of this molecule in the solid state.
  • Hydrogen bonding interactions are critical for the observed crystal packing of C(12)H(17)NO(3).
  • This study provides insights into the structure-property relationships of related organic compounds.