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Updated: Jun 1, 2026
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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
4-Amino-2,3,5-trimethyl-pyridine monohydrate
Summary
This study reveals a unique crystal structure where pyridine and water molecules form alternating large rings through hydrogen bonds. These rings interconnect to create an intricate three-dimensional network.
Area of Science:
- Crystal Engineering
- Supramolecular Chemistry
- Materials Science
Background:
- Understanding the self-assembly of organic molecules with water is crucial for designing novel materials.
- Hydrogen bonding interactions play a pivotal role in dictating crystal packing and network formation.
Purpose of the Study:
- To elucidate the crystal structure of a specific substituted pyridine hydrate.
- To investigate the hydrogen bonding patterns that govern the assembly of the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding interactions (O-H···N and N-H···O) was performed.
Main Results:
- The crystal structure of C(8)H(12)N(2)·H(2)O features an alternating arrangement of four substituted pyridine molecules and four water molecules.
- These molecules form a large ring through intermolecular hydrogen bonds: O(water)-H⋯N(pyridine) and N(amine)-H⋯O(water).
- Adjacent large rings are further linked by O(water)-H⋯O(water) hydrogen bonds, resulting in a robust three-dimensional network.
Conclusions:
- The study successfully characterized a novel supramolecular assembly driven by specific hydrogen bonding motifs.
- The observed 3D network highlights the potential for designing ordered crystalline materials through rational molecular design.
