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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
1-{2-[(4-Hydr-oxy-3-methoxy-benzyl-idene)amino]eth-yl}-3-methylimid-azolium hexa-fluoro-phosphate
1Department of Chemistry, Jinan University, Guangzhou 510632, People's Republic of China.
Abstract:
In the title Schiff base salt, C(14)H(18)N(3)O(2) (+)·PF(6) (-), the dihedral angle between the planes of the aromatic and imidazole rings is 24.84 (8)°. The mol-ecular structure exhibits an intra-molecular O-H⋯O hydrogen bond, which generates an S(5) ring motif. In the crystal structure, the cations and anions are connected via O-H⋯N and O-H⋯F hydrogen bonds, resulting in a trifurcated interaction for the phenolic H atom.
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