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Updated: Jun 1, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
(R,R)-N,N'-Bis(ferrocenylmeth-yl)cyclo-hexane-1,2-diamine
1Ordered Matter Science Research Center, College of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
The study reveals the chair configuration of a cyclo-hexane ring in a novel iron compound, with equatorial ferrocenemethyl-amino groups. Intra-molecular hydrogen bonding likely influences the ferrocene nuclei arrangement.
Area of Science:
- Organometallic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- Ferrocene derivatives are crucial in organometallic chemistry due to their unique electronic and structural properties.
- Understanding the conformational preferences and intermolecular interactions of complex organometallic compounds is vital for designing new materials.
Purpose of the Study:
- To elucidate the three-dimensional structure and conformational analysis of the title compound, [Fe(2)(C(5)H(5))(2)(C(18)H(24)N(2))].
- To investigate potential intramolecular interactions influencing the observed molecular geometry.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the precise atomic arrangement of the compound.
- Conformational analysis of the cyclo-hexane ring and the ferrocene moieties was performed.
Main Results:
- The cyclo-hexane ring adopts a chair configuration.
- Two ferrocenemethyl-amino groups are equatorially substituted on the cyclo-hexane ring.
- The arrangement of the ferrocene nuclei suggests possible intra-molecular N-H⋯N hydrogen bonding.
Conclusions:
- The structural study confirms the expected equatorial disposition of the bulky ferrocenemethyl-amino substituents.
- Intra-molecular hydrogen bonding is proposed as a stabilizing factor for the observed configuration of the ferrocene nuclei.
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