Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Basicity of Heterocyclic Aromatic Amines01:25

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
Five-Membered Heterocyclic Aromatic Compounds: Overview01:13

Five-Membered Heterocyclic Aromatic Compounds: Overview

Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom, respectively.
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is platinum the new gold? Re-evaluating platinum's enduring role and future potential in the era of novel ovarian cancer therapies.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Prospective Cohort Study: Hexyl-2,5-Diaminobenzoate Is a Hypoallergenic Alternative for Patients With Allergic Contact Dermatitis to Para-Phenylenediamine.

Dermatitis : contact, atopic, occupational, drug·2026
Same author

Access to Substituted Pyrimidines via Isoxazole Ring Transformation in Three-Component Reactions with Amines and Orthoesters.

Organic letters·2026
Same author

Novel therapeutic topical gel approach for chronic inflammation and pain management in osteo- and viral-arthritis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Nano-biohybrid systems for the targeted delivery of chemotherapeutics.

Nanoscale·2025
Same author

A virtual factory for topical formulations based on molecular modeling and drug-polymer interaction studies.

Drug delivery and translational research·2025

Related Experiment Video

Updated: Jun 1, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

4-Hydrazino-1-methyl-pyrazolo[3,4-d]pyrimidine.

Anton V Dolzhenko, Giorgia Pastorin, Anna V Dolzhenko

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    This study details the crystal structure of a nitrogen-rich compound, C(6)H(8)N(6). It reveals how molecules self-assemble into dimers and chains through specific hydrogen bonds, influencing crystal packing.

    More Related Videos

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
    07:12

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

    Published on: July 17, 2020

    Facile Preparation of 4-Substituted Quinazoline Derivatives
    11:51

    Facile Preparation of 4-Substituted Quinazoline Derivatives

    Published on: February 15, 2016

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
    05:07

    Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

    Published on: June 23, 2019

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
    07:12

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

    Published on: July 17, 2020

    Facile Preparation of 4-Substituted Quinazoline Derivatives
    11:51

    Facile Preparation of 4-Substituted Quinazoline Derivatives

    Published on: February 15, 2016

    Area of Science:

    • Crystallography
    • Supramolecular Chemistry
    • Materials Science

    Background:

    • Understanding the self-assembly of organic molecules is crucial for designing novel materials.
    • Hydrogen bonding plays a significant role in directing crystal packing and molecular architecture.

    Purpose of the Study:

    • To elucidate the crystal structure of the title compound C(6)H(8)N(6).
    • To investigate the intermolecular interactions, specifically hydrogen bonding, that govern its solid-state arrangement.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
    • Analysis of hydrogen bonding networks using graph-set notation.

    Main Results:

    • The compound crystallizes as N-H⋯N hydrogen-bond-linked dimers in the asymmetric unit.
    • These dimers form extended chains along the [100] direction via intermolecular N-H⋯N hydrogen bonds.
    • Weak C-H⋯N hydrogen bonds further link these chains, creating a three-dimensional network.

    Conclusions:

    • The crystal structure is dictated by a combination of strong N-H⋯N and weaker C-H⋯N hydrogen bonds.
    • The observed hydrogen bonding patterns (C(7) and C(4) motifs) lead to a specific supramolecular architecture.
    • This detailed structural understanding provides insights into the solid-state behavior of nitrogen-rich compounds.