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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N-(4-Hydroxy-pheneth-yl)acetamide.
Bo Wang1, Yun Chai, Peizhen Tao
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100050, People's Republic of China.
This study reveals how hydrogen bonds in a C(10)H(13)NO(2) compound create tetra-mers. These molecular assemblies form corrugated sheets, offering insights into crystal structure formation.
Area of Science:
- Crystallography
- Supramolecular Chemistry
- Materials Science
Background:
- Hydrogen bonding plays a crucial role in molecular self-assembly.
- Understanding crystal packing is essential for predicting material properties.
Purpose of the Study:
- To elucidate the hydrogen bonding network and self-assembly behavior of the title compound C(10)H(13)NO(2).
- To characterize the resulting supramolecular structures at the molecular level.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure and crystal packing.
- Analysis of intermolecular interactions, including hydrogen bonds, was performed.
Main Results:
- The compound forms tetra-mers through intermolecular N-H⋯O and O-H⋯O hydrogen bonds between hydroxyl and acetamido groups.
- These tetra-mers exhibit an R(4)(4)(25) graph-set motif.
- The tetra-mers further assemble into corrugated sheets parallel to the (001) crystallographic plane.
Conclusions:
- The specific hydrogen bonding interactions dictate the formation of defined supramolecular architectures.
- The observed sheet formation provides a fundamental understanding of crystal growth and material design for C(10)H(13)NO(2).
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