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Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

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Phase II Reactions: Glucuronidation

Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...

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Aryldiazonium Salts to Azo Dyes: Diazo Coupling

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Related Experiment Video

Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

2-Hydroxy-benzoic acid-purin-6-amine (3/1).

Lian-Cai Du, Wu-Lan Zeng, Xue-Ying Liu

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This study details a 3:1 adduct formed by 2-hydroxy-benzoic acid and a nitrogen-containing molecule. It reveals intramolecular hydrogen bonds within the acid and intermolecular bonds connecting the adduct components in the crystal structure.

Area of Science:

Crystallography
Supramolecular Chemistry
Chemical Physics

Background:

Hydrogen bonding plays a crucial role in molecular self-assembly and crystal engineering.
Understanding intermolecular interactions is key to designing novel materials with specific properties.

Purpose of the Study:

To characterize the crystal structure of a 3:1 adduct involving 2-hydroxy-benzoic acid.
To investigate the nature and role of intra- and intermolecular hydrogen bonds in the adduct.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
Analysis of hydrogen bonding networks was performed based on crystallographic data.

Main Results:

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

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Last Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

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Published on: February 15, 2016

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

The 3:1 adduct, with the chemical formula C(7)H(6)O(3)·C(5)H(5)N(5), was successfully synthesized and characterized.

Intramolecular O-H⋯O hydrogen bonds were observed within each 2-hydroxy-benzoic acid molecule.

Intermolecular N-H⋯O and O-H⋯N hydrogen bonds link the components in the crystal lattice.

Conclusions:

The crystal structure reveals a specific arrangement driven by both intramolecular and intermolecular hydrogen bonding.
The study provides insights into the supramolecular assembly of 2-hydroxy-benzoic acid with nitrogen-containing compounds.