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Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
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Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
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Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
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Facile Preparation of 4-Substituted Quinazoline Derivatives
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1,3-Benzothia-zol-2-amine.

Muhammad Altaf1, Helen Stoeckli-Evans

  • 1Institute of Physics, University of Neuchâtel, rue Emile-Argand 11, CH-2009 Neuchâtel, Switzerland.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary
This summary is machine-generated.

This study reveals the crystal structure of C(7)H(6)N(2)S, detailing how molecules form dimers through hydrogen bonds. These dimers further assemble into a 2D network, offering insights into molecular assembly and crystal engineering.

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Area of Science:

  • Crystallography
  • Materials Science
  • Chemical Physics

Background:

  • Understanding molecular interactions is crucial for designing new materials.
  • Hydrogen bonding plays a significant role in supramolecular chemistry and crystal engineering.
  • The specific compound C(7)H(6)N(2)S has potential applications that warrant structural investigation.

Purpose of the Study:

  • To elucidate the crystal structure of the title compound, C(7)H(6)N(2)S.
  • To identify and characterize the hydrogen bonding interactions present in the crystal lattice.
  • To describe the resulting supramolecular architecture formed by these interactions.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the three-dimensional crystal structure.
  • Analysis of intermolecular distances and angles identified key hydrogen bonding motifs.
  • Crystal structure visualization software was used to illustrate the molecular arrangement and network formation.

Main Results:

  • The crystal structure of C(7)H(6)N(2)S was successfully determined.
  • Molecules are linked by N-H⋯N hydrogen bonds, forming discrete dimers.
  • These dimers are further connected by additional N-H⋯N hydrogen bonds, creating an extended two-dimensional network parallel to the (011) plane.

Conclusions:

  • The crystal packing of C(7)H(6)N(2)S is dominated by N-H⋯N hydrogen bonding.
  • The formation of dimers and a 2D network highlights the directional nature of these interactions.
  • The detailed structural information provides a basis for understanding the compound's physical properties and potential applications.