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Solvents

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A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
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A generic acid (HA) reacts with the generic base (B-) to yield the corresponding conjugate base (A-) and conjugate acid (HB):

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Related Experiment Video

Updated: Jun 1, 2026

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

Abacavir methanol 2.5-solvate.

Phuong-Truc T Pham¹

¹Department of Chemistry, Penn State Worthington Scranton, 120 Ridge View Drive, Dunmore, Pennsylvania 18512, USA.

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This summary is machine-generated.

The crystal structure of abacavir, an essential antiviral drug, reveals hydrogen-bonded ribbons. These ribbons form a stable structure through interactions involving hydroxyl and purine nitrogen atoms.

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Area of Science:

Crystallography
Medicinal Chemistry
Structural Biology

Background:

Abacavir is a crucial nucleoside reverse transcriptase inhibitor used in treating HIV/AIDS.
Understanding the precise molecular structure of abacavir is vital for drug design and development.

Purpose of the Study:

To elucidate the detailed crystal structure of abacavir.
To characterize the intermolecular interactions stabilizing the abacavir crystal lattice.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the structure.
The SQUEEZE subroutine in PLATON was utilized to handle disordered solvent molecules.

Main Results:

The structure of abacavir (C14H18N6O) was determined, showing a crystal form solvated with 2.5 methanol molecules.
Abacavir molecules form hydrogen-bonded ribbons stabilized by interactions between hydroxyl groups and purine N atoms.

Conclusions:

The determined crystal structure provides a detailed 3D molecular model of abacavir.
This structural information can inform the development of next-generation antiviral agents.