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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4-(4-Bromo-phen-yl)-5-oxo-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2-thione
Min Xie1, Changquan Deng, Jie Zheng
1School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.
Abstract:
The title compound, C(14)H(13)BrN(2)OS, was synthesized from the multicomponent reaction between thio-urea, 4-bromo-benzaldehyde and cyclo-hexane-1,3-dione. The crystal packing is stabilized by inter-molecular N-H⋯O, N-H⋯S, C-H⋯O and C-H⋯S hydrogen bonds. Br⋯O inter-actions [3.183 (3) Å] are also observed in the crystal structure.
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