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Painful ophthalmoplegia caused by neurotropic malignant melanoma
T J Hufnagel1, P J Savino, R A Zimmerman
1Department of Ophthalmology, Yale University School of Medicine, New Haven, Connecticut.
Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|February 1, 1990
Abstract:
Progressive cranial nerve palsies and painful ophthalmoplegia developed in a 76-year-old man with lentigo maligna of the forehead 18 months after the excision of a spindle cell tumour of the forehead that proved on immunohistochemical study to be a malignant melanoma. The signs and symptoms were caused by neurotropic spread of the malignant melanoma into the cavernous sinus and subsequent neurosarcomatous transformation of the orbital metastasis.