Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2-(2,2,4-trimethyl-6-tosyl-perhydro-1,3-dioxino[5,4-c]pyridin-5-yl)acetate
Abstract:
The title compound, C(20)H(29)NO(6)S, crystallizes with two mol-ecules in the asymmetric unit, with similar conformations. The dioxane and pyridine rings adopt twist conformations in both mol-ecules. The packing is stabilized by inter-molecular C-H⋯O hydrogen bonds.
Related Concept Videos
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...

