Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Cycloalkanes02:28

Cycloalkanes

Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous overlap of p...
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that was based on the...
Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imperatorin from the aerial parts of <i>Cleome viscosa</i> L.: a characterization study and evaluation of the antibacterial activity.

Natural product research·2023
Same author

Multi-sensory feedback improves spatially compatible sensori-motor responses.

Scientific reports·2022
Same author

Tris(ethane-1,2-di-amine-κ<sup>2</sup> <i>N</i>,<i>N</i>')zinc(II) tetra-chlorido-zincate(II).

IUCrData·2022
Same author

Interacting humans use forces in specific frequencies to exchange information by touch.

Scientific reports·2022
Same author

Numerical estimation of calibration matrices for <sup>241</sup>Am measurements using HPGe based in-vivo monitoring system.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2022
Same author

STUDY OF EFFECTIVENESS OF SHELTERING FROM RADIATION EXPOSURE DUE TO ACCIDENTAL RELEASE OF RADIOACTIVITY.

Radiation protection dosimetry·2022

Related Experiment Video

Updated: Jun 1, 2026

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
09:45

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

Published on: March 20, 2017

Cyclo-hexane-1,2,3,4,5-pentol.

G Ganesh, C Sivaraj, P S Kannan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    The crystal structure of a C(6)H(12)O(5) compound reveals a cyclohexane ring in a chair conformation. Molecules form a 3D network through strong intermolecular hydrogen bonds, with a defined relative configuration of 1R*,3R*,4S*,S*.

    More Related Videos

    Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
    09:35

    Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

    Published on: September 18, 2016

    Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
    08:12

    Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

    Published on: December 16, 2022

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
    09:45

    Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

    Published on: March 20, 2017

    Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
    09:35

    Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

    Published on: September 18, 2016

    Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
    08:12

    Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

    Published on: December 16, 2022

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Structural Chemistry

    Background:

    • Understanding the three-dimensional structure of organic compounds is crucial for predicting their properties and reactivity.
    • Cyclohexane derivatives are fundamental building blocks in many natural products and pharmaceuticals.

    Purpose of the Study:

    • To elucidate the crystal structure and molecular arrangement of the title compound, C(6)H(12)O(5).
    • To determine the conformation and relative stereochemistry of the cyclohexane ring.
    • To investigate intermolecular interactions within the crystal lattice.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was employed to determine the molecular and crystal structure.
    • Analysis of bond lengths, bond angles, and torsion angles to define the cyclohexane conformation.
    • Identification and analysis of intermolecular interactions, particularly hydrogen bonding.

    Main Results:

    • The cyclohexane ring adopts a chair conformation.
    • The relative configuration was assigned as 1R*,3R*,4S*,S*.
    • Strong intermolecular O-H⋯O hydrogen bonds link molecules, forming an extensive three-dimensional network in the crystal structure.

    Conclusions:

    • The study provides detailed structural information about the C(6)H(12)O(5) compound.
    • The observed crystal packing is dominated by robust hydrogen bonding, influencing the material's properties.
    • The determined relative configuration is essential for further synthetic and biological studies.