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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
(E)-N'-(2,5-Dimethoxy-benzyl-idene)-2-(8-quinol-yloxy)acetohydrazide methanol solvate
Summary
This study details the crystal structure of a novel acetohydrazide compound, revealing specific hydrogen bonding and π-π interactions that influence its molecular arrangement and packing in the solid state.
Area of Science:
- Crystallography
- Supramolecular Chemistry
- Organic Chemistry
Background:
- Acetohydrazide derivatives are important in medicinal chemistry.
- Understanding intermolecular interactions is crucial for crystal engineering and materials science.
Purpose of the Study:
- To elucidate the crystal structure of a novel acetohydrazide compound.
- To characterize the hydrogen bonding and π-π interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of intermolecular interactions, including hydrogen bonds and π-π stacking, was performed.
Main Results:
- The asymmetric unit contains two acetohydrazide molecules and one methanol molecule.
- Key intermolecular interactions include O-H⋯(O,N), N-H⋯O, and C-H⋯O hydrogen bonds.
- The molecular skeleton is nearly planar, with a small dihedral angle between benzene and quinoline rings (3.9°).
- Crystal packing is influenced by weak intermolecular C-H⋯O hydrogen bonds and π-π interactions (3.668 Å).
Conclusions:
- The crystal structure is stabilized by a network of hydrogen bonds and π-π interactions.
- The observed interactions provide insights into the self-assembly and packing behavior of this acetohydrazide derivative.
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