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Obsessive - compulsive symptoms during clozapine treatment
1A.K. AGARWAL, M.D., D.P.M., Professor & Head, Department of Psychiatry, K.G. Medical College, Lucknow-226003.
Indian Journal of Psychiatry
|May 18, 2011
Summary
Clozapine treatment in schizophrenic patients may lead to obsessive-compulsive symptoms. Vigilance for these symptoms is recommended due to clozapine
Area of Science:
- Psychiatry and Pharmacology
Background:
- Obsessive-compulsive symptoms (OCS) are infrequently reported during clozapine treatment in Western literature.
- Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia.
Purpose of the Study:
- To report the development of OCS in three patients with treatment-resistant schizophrenia during clozapine therapy.
- To consider the potential role of serotonergic systems in OCS development during clozapine treatment.
Main Methods:
- Case series of three patients with schizophrenia resistant to typical antipsychotics.
- Observation of symptom development during clozapine administration.
Main Results:
- Three patients developed obsessive-compulsive symptoms while undergoing clozapine treatment.
- These patients were previously resistant to typical antipsychotic medications.
Conclusions:
- The development of OCS during clozapine treatment warrants attention.
- The potent 5-HT(2) receptor blockade by clozapine suggests a potential role for serotonergic pathways in OCS.
- Clinicians should monitor all patients on clozapine for emerging OCS.
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