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Obsessive - compulsive symptoms during clozapine treatment
1A.K. AGARWAL, M.D., D.P.M., Professor & Head, Department of Psychiatry, K.G. Medical College, Lucknow-226003.
Abstract:
Development of obsessive-compulsive symptoms during clozapine treatment in schizophrenics has been noted in few reports from west. In our cases, three schizophrenic patients resistant to typical antipsychotics developed obsessive-compulsive symptoms during clozapine treatment. Since clozapine is a potent 5-HT(2) receptor blocker, role of serotonergic systems in the development of obsessive-compulsive symptoms may be considered. It may be prudent to be vigilant for the emergence of obsessive-compulsive symptoms in all patients treated with clozapine.
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