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Updated: Jun 1, 2026
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite
Estefanía Delgado-Pinar1, M Teresa Albelda, Juan C Frías
1Instituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, Edificio de Institutos de Paterna, C/Catedrático José Beltrán 2, Apartado de Correos 22085, 46071, Valencia, Spain.
Abstract:
The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.
