Differences in the tumor DNA analysis of a hepatocellular-carcinoma and a synchronous fibrolamellar variant

A 60 year old man had two tumours resected from his liver which were shown histologically to be a well differentiated hepatocellular carcinoma and the fibrolamellar variant. Both are considered clinically distinct and of different pathogenesis and have not been previously reported occurring synchronously. DNA analysis revealed allele loss on chromosome 12 in the hepatocellular carcinoma which was not found in the fibrolamellar variant. This finding may suggest that hepatocellular carcinoma and fibrolamellar variant may have different molecular-genetic mechanisms for the development, in addition to their clinico-pathological difference.