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Published on: October 30, 2013
Preoperative radiotherapy for muscle-invading bladder-carcinoma
1BOWMAN GRAY SCH MED,DEPT RADIOL,MED CTR BLVD,WINSTON SALEM,NC 27157. BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,WINSTON SALEM,NC 27157. DUKE UNIV,MED CTR,DIV RADIAT ONCOL,DURHAM,NC 27710.
International Journal of Oncology
|May 18, 2011
Summary
Preoperative radiotherapy (RT) followed by cystectomy shows promising local control for transitional cell bladder carcinoma. Survival and complication rates were similar across low-dose and high-dose RT regimens, supporting its use in select patients.
Area of Science:
- Urology
- Oncology
- Radiation Oncology
Background:
- Transitional cell bladder carcinoma (T2-T4) requires effective treatment strategies.
- Preoperative radiotherapy (RT) followed by cystectomy is a treatment option.
- Optimizing RT dosage for bladder cancer is crucial.
Purpose of the Study:
- To evaluate the efficacy of low-dose versus high-dose preoperative radiotherapy (RT) in patients with transitional cell bladder carcinoma.
- To assess the impact of preoperative RT on survival, local control, distant metastasis, and complications.
- To determine the optimal preoperative RT regimen for bladder cancer treatment.
Main Methods:
- Retrospective review of 105 patients with clinical stage T2-T4 transitional cell bladder carcinoma.
- Patients received either low-dose (20-26 Gy) or high-dose (40-50 Gy) preoperative RT followed by cystectomy.
- Analysis of 5-year actuarial survival, local control rates, distant metastasis, and complications.
Main Results:
- Five-year survival rates were 42% (T2), 52% (T3), and 17% (T4).
- Five-year local control rates were 93% (T2), 93% (T3), and 22% (T4).
- No significant differences in survival, local control, metastasis, or complications were observed between low-dose and high-dose RT regimens.
Conclusions:
- Preoperative radiotherapy (RT) demonstrates high local control rates in select bladder cancer patients.
- Both low-dose and high-dose preoperative RT regimens yield similar outcomes.
- The findings support the use of preoperative RT in managing transitional cell bladder carcinoma.
