Related Experiment Video
Updated: Jun 1, 2026
12:47
Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
Published on: February 3, 2012
Methylation of chromosome 11p genes in wilms-tumor and kidney tissue
J Williams1, N Maitland, M Mott
1UNIV WALK,SCH MED SCI,DEPT PATHOL & MICROBIOL,CANC & LEUKAEMIA CHILDHOOD TRUST LAB,BRISTOL BS8 1TD,ENGLAND.
International Journal of Oncology
|May 18, 2011
Abstract:
Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney cells.
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