Related Experiment Video
Updated: Jun 1, 2026

Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
Mitochondria as a target for combination cancer-chemotherapy
1MCMASTER UNIV,HAMILTON REG CANC CTR,ONTARIO CANC FDN,HAMILTON L8N 3Z5,ONTARIO,CANADA.
Abstract:
The purpose of this study was to examine whether mitochondria could be used as a potential target for combination cancer chemotherapy. Mitochondrial specific agents, namely Dequalinium chloride and Rhodamine 123 were tested as single agent and in combination with cis-diammine dichloroplatinum (II). Combination of either cis-diammine dichloroplatinum (II) and Rhodamine 123 or cis-diammine dichloroplatinum (II) and Dequalinium chloride showed that there was a synergistic action. However, combination of Rhodamine 123 and Dequalinium chloride showed a slight antagonistic activity which could be due to competition for the same site. The data also show that a much lower dose of cisplatin is required to produce an equieffective-response when used in combination with Dequalinium chloride and thus may lower the cis-diammine dichloroplatinum (II) induced toxicities.
More Related Videos
07:58An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity
Published on: May 12, 2020
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
Related Concept Videos
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...