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STR markers for detecting heterogeneity in Indian population
Shalu Jain1, Inusha Panigrahi, Jayesh Sheth
1Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raibareilly Road, Lucknow, 226014, India.
Molecular Biology Reports
|May 18, 2011
Summary
Short tandem repeats (STRs) are vital genetic markers. This study analyzed four STR markers in the Indian population, finding them highly polymorphic and useful for genetic studies.
Area of Science:
- Genetics
- Molecular Biology
Background:
- Short tandem repeats (STRs) are repetitive DNA sequences abundant in eukaryotic genomes.
- STRs constitute approximately 3% of the human genome and are crucial genetic markers.
- Their high polymorphism, small size, and low mutation rates make them valuable for genetic mapping, disease diagnosis, and identity testing.
Purpose of the Study:
- To analyze the allelic distribution of four autosomal STR markers (D21S2055, D21S11, D21S1435, and D21S1411) in the Indian population.
- To determine the heterogeneity and allelic frequencies of these STR markers.
Main Methods:
- Quantitative fluorescent polymerase chain reaction (QF-PCR) analysis was employed.
- Allelic distribution and frequencies of four specific STR loci were determined.
Main Results:
- All analyzed STR loci exhibited high levels of polymorphism in the Indian population.
- Marker D21S1411 was identified as the most informative (93.6% informativeness).
- Marker D21S1435 was found to be the least informative (70.1% informativeness).
Conclusions:
- The analyzed autosomal STR markers are highly polymorphic in the Indian population.
- These STR markers, particularly D21S1411, are valuable genetic tools for various applications within this demographic.
- The findings contribute to the understanding of genetic diversity and STR marker utility in India.
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