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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

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Published on: January 7, 2015

Sorafenib-associated multivessel coronary artery vasospasm

T Naib1, R M Steingart, C L Chen

  • 1Division of Cardiology, Memorial Sloan-Kettering Cancer Center, New York, USA.

Herz
|May 18, 2011
PubMed

Insights

Vascular endothelial growth factor pathway inhibitors (VSP) can cause cardiotoxicity. This study reports the first case of sorafenib-induced multivessel coronary vasospasm, a reversible side effect.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Cancer therapies increasingly utilize VEGF signaling pathway inhibitors (VSP).
  • These inhibitors target VEGFRs and other kinases crucial for vascular and myocardial homeostasis.
  • Hypertension is a common side effect, but VSP-related myocardial ischemia is poorly understood.

Observation:

  • A 57-year-old patient with hepatocellular carcinoma developed multivessel coronary vasospasm.
  • The patient was undergoing treatment with sorafenib, a tyrosine kinase inhibitor.
  • Coronary vasospasm resolved upon administration of nitroglycerin.

Findings:

  • This is the first reported case of sorafenib-associated multivessel coronary vasospasm.
  • Sorafenib, a VSP inhibitor, can induce coronary artery vasospasm.
  • The vasospastic event was reversible with medical intervention.

Implications:

  • Highlights a potential mechanism for cardiotoxicity with VSP inhibitors.
  • Suggests the need for vigilance regarding coronary vasospasm in patients receiving sorafenib.
  • Warrants further investigation into the mechanisms of VSP inhibitor-induced cardiovascular events.

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