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Related Experiment Video

Updated: Jun 1, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Off-pump surgery for the poor ventricle?

Maximilian Y Emmert¹, Sacha P Salzberg, Oliver M Theusinger

¹Department of Cardiovascular Surgery, University Hospital Zurich, Raemi Street 100, 8091, Zurich, Switzerland. maximilian.emmert@web.de

Heart and Vessels

|May 18, 2011

Summary

This summary is machine-generated.

Off-pump coronary artery bypass grafting (OPCAB) is safe for patients with severely reduced ejection fraction (EF), showing similar mortality and major adverse cardiac and cerebrovascular events (MACCE) compared to on-pump CABG (ONCABG). OPCAB may reduce non-cardiac complications without compromising complete revascularization.

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Last Updated: Jun 1, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

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Published on: May 11, 2018

Area of Science:

Cardiovascular Surgery
Cardiac Anesthesia

Background:

Severely decreased ejection fraction (EF) is a significant risk factor for adverse outcomes following cardiac surgery.
Comparing surgical techniques in patients with compromised EF is crucial for optimizing patient care.

Purpose of the Study:

To compare the outcomes of off-pump coronary artery bypass grafting (OPCAB) versus on-pump CABG (ONCABG) in patients with severely reduced EF (≤35%).
To assess the safety, efficacy, and complication rates of OPCAB versus ONCABG in this high-risk population.

Main Methods:

A cohort of 478 patients with EF ≤35% undergoing myocardial revascularization between 2004-2009 were analyzed.
Patients received either OPCAB (n=256) or ONCABG (n=222).
Propensity score (PS) matching and adjusted logistic regression were used to compare mortality, MACCE, and non-cardiac complications.

Main Results:

No significant differences were observed in mortality (2.3% vs. 4.1%) or MACCE (13.7% vs. 17.6%) between OPCAB and ONCABG groups.
OPCAB showed a trend towards fewer non-cardiac complications (12.1% vs. 22.1%), including renal dysfunction and bleeding.
The rate of complete revascularization was similar between the two groups (92.2% vs. 92.8%).

Conclusions:

Off-pump coronary artery bypass grafting (OPCAB) is a safe and feasible option for patients with severely decreased ejection fraction.
OPCAB may offer a potential benefit in reducing non-cardiac complications without compromising the completeness of revascularization.
These findings support OPCAB as a viable alternative for myocardial revascularization in high-risk patients with compromised cardiac function.