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A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Molecularly imprinted polyaniline film for ascorbic acid detection.

Abani Kumar Roy¹, V S Nisha, Chetna Dhand

¹Department of Science & Technology Centre on Biomolecular Electronics, National Physical Laboratory (Council of Scientific and Industrial Research), Dr. K.S. Krishnan Marg, New Delhi 110012, India.

Journal of Molecular Recognition : JMR

|May 18, 2011

Summary

Researchers developed a novel ascorbic acid (AA) sensor using molecularly imprinted polyaniline (PANI) film. This PANI-based electrode demonstrates high sensitivity and selectivity for detecting AA, offering a stable and reusable sensing platform.

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Area of Science:

Electrochemistry
Materials Science
Analytical Chemistry

Background:

Polyaniline (PANI) films are versatile conducting polymers.
Molecular imprinting creates selective binding sites for target molecules.
Ascorbic acid (AA) is an important biomolecule with various applications.

Purpose of the Study:

To electrochemically fabricate a molecularly imprinted polyaniline (PANI) film for ascorbic acid (AA) detection.
To develop a selective and sensitive electrochemical sensor for AA.
To investigate the performance characteristics of the developed sensor.

Main Methods:

Electrochemical fabrication of PANI film on ITO-coated glass using AA as a template.
Characterization using Fourier transform infra-red spectroscopy and scanning electron microscopy.

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Electrochemical analysis via cyclic voltammetry and differential pulse voltammetry (DPV).

Main Results:

Successful fabrication of a ∼100 nm thick PANI film with embedded AA moieties, acting as a dopant.
Development of an AA-selective molecularly imprinted PANI electrode (AA-MI-PANI/ITO) after over-oxidation.
The AA-MI-PANI/ITO electrode detected AA in the range of 0.05-0.4 mM with a detection limit of 0.018 mM and sensitivity of 1.2 × 10⁻⁵ A/mM.

Conclusions:

The developed AA-MI-PANI/ITO electrode exhibits excellent reusability, selectivity, and stability for AA detection.
This molecularly imprinted polymer sensor offers a promising platform for sensitive and selective electrochemical sensing of AA.
The study highlights the potential of PANI-based molecularly imprinted materials in analytical applications.