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Effect of sex hormones on crystal formation in a stone-forming rat model
Iwao Yoshioka1, Masao Tsujihata, Akihiko Okuyama
1Osaka University Graduate School of Medicine, Suita, Japan. yoshioka@uro.med.osaka-u.ac.jp
Abstract:
Sex hormones have substantial effects on crystal formation in the rat kidney through oxalate metabolism and oxidative cell damage. Testosterone is a promoter and estradiol an inhibitor of such crystal formation. The development of new medications related to sex hormones or GO are anticipated for sufferers of recurrent urolithiasis.
