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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Antiangiogenic anticancer strategy based on nanoparticulate systems.

Krassimira Yoncheva1, Georgi Momekov

  • 1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Sofia, Bulgaria. krassi.yoncheva@gmail.com

Expert Opinion on Drug Delivery
|May 19, 2011
PubMed
Summary

Nanoparticulate systems offer improved delivery and targeting for antiangiogenic cancer therapies. These nanoparticles enhance drug penetration and efficacy, reducing required drug doses for better treatment outcomes.

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Area of Science:

  • Nanomedicine and Cancer Therapeutics
  • Drug Delivery Systems
  • Molecular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and survival.
  • Antiangiogenic strategies aim to inhibit tumor blood supply, but face challenges like drug toxicity and instability.
  • Targeted delivery of antiangiogenic agents to tumor vasculature can enhance treatment efficacy.

Purpose of the Study:

  • To review the application of nanoparticulate systems for antiangiogenic therapy.
  • To explore how nanoparticle properties facilitate targeted delivery and improved therapeutic outcomes.
  • To discuss nanoparticle conjugation strategies for targeting specific angiogenic markers.

Main Methods:

  • Focus on nanoparticulate systems including nanoparticles, liposomes, and polymeric micelles.
  • Analysis of key nanoparticle properties: size, charge, and surface modification for targeting and delivery.
  • Review of examples of nanoparticle conjugation for targeting growth factors (e.g., VEGF, FGF) and enzymes (e.g., MMPs).

Main Results:

  • Nanoparticles possess properties suitable for targeting endothelial cells and delivering antiangiogenic agents.
  • Surface modification and conjugation enable specific targeting of tumor vasculature markers.
  • Targeted nanoparticles demonstrate potential for improved drug delivery and therapeutic effects.

Conclusions:

  • Targeted nanoparticles facilitate co-administration of antiangiogenic and anticancer drugs.
  • Nanoparticle targeting improves drug penetration into tumor tissues.
  • Enhanced therapeutic effects are achievable with reduced drug doses using targeted nanoparticles.