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Updated: Jun 1, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
Published on: November 9, 2017
Signaling mechanisms for chemotaxis
Yu Wang1, Chun-Lin Chen, Miho Iijima
1Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract:
Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.
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