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Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines
J L Kelley1, J A Linn, J W Selway
1Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
Journal of Medicinal Chemistry
|May 1, 1990
Abstract:
A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.