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IL-1 polymorphisms in children with peptic symptoms in South China

Juan Li1, Fangjin Wang, Qiang Zhou

  • 1Department of Laboratories, the Second Affiliated Hospital of GuangZhou Medical University, Guangzhou, China.

Helicobacter
|May 19, 2011
PubMed

Insights

Interleukin-1 (IL-1) gene polymorphisms, specifically IL-1B-511TT/-31CC, are linked to severe gastric changes in children. This finding suggests a genetic predisposition to gastritis and ulcers in young individuals in South China.

Area of Science:

  • Genetics
  • Gastroenterology
  • Pediatrics

Background:

  • Interleukin-1 (IL-1) gene cluster polymorphisms are linked to gastric mucosal changes and IL-1β expression in adults, particularly with H. pylori infection.
  • H. pylori virulence differs between adults and children, necessitating specific research in pediatric populations.

Purpose of the Study:

  • To investigate the association between IL-1 gene polymorphisms and gastric mucosal histological changes in young children in South China.
  • To determine if IL-1 polymorphisms are risk factors for peptic symptoms in pediatric patients.

Main Methods:

  • Genotyping of IL-1B-511, IL-1B-31, and IL-1RN polymorphisms in 128 children with peptic symptoms.
  • Analysis of IL-1β mRNA expression using real-time PCR ddCT assay.
  • Correlation of genetic data with gastric mucosal histology and H. pylori status.

Main Results:

  • IL-1B-31T and IL-1B-511C polymorphisms were found to be completely linked.
  • Significant differences in IL-1B-511/-31 genotypes were observed across different clinical outcomes (p=0.001).
  • The IL-1B-511TT/-31CC genotype was prevalent (60.7%) in children with moderate to severe gastritis or gastric ulcers. No association was found between IL-1RN genotypes, H. pylori infection, or IL-1β mRNA expression and gastric histology.

Conclusions:

  • Children with the IL-1B-511TT/-31CC genotype may be at increased risk for developing severe gastric mucosal histological changes.
  • These findings highlight the potential role of specific IL-1 gene polymorphisms in pediatric gastric disease susceptibility in South China.
Abstract

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