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Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...

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Related Experiment Videos

Marjolin ulcer: an overlooked entity.

Sasha Pavlovic1, Elizabeth Wiley, Grace Guzman

  • 1Department of Pathology, College of Medicine, University of Illinois, Chicago, IL 60612, USA. spavlo2@uic.edu

International Wound Journal
|May 19, 2011
PubMed
Summary
This summary is machine-generated.

Marjolin ulcer, a rare malignancy in chronic wounds, often arises from burn scars. Early detection and surgical excision are crucial for managing this squamous cell carcinoma.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Marjolin ulcer is a rare malignancy developing in chronic wounds and scars, first described in 1828.
  • It is frequently overlooked, leading to delayed diagnosis and poor patient outcomes.
  • Malignant transformation typically occurs in burn scars but also in other chronic non-healing wounds.

Observation:

  • The development of malignancy is a slow process, averaging about 25 years.
  • Well-differentiated squamous cell carcinoma (SCC) is the most common histological type.
  • This case report details a Marjolin ulcer on the buttock in a patient with a history of traumatic wound.

Findings:

  • Biopsy with histopathology is the gold standard for diagnosing Marjolin ulcer.
  • Radical surgical excision is the primary treatment of choice.
  • A high index of suspicion is necessary for healthcare providers evaluating chronic wounds.

Implications:

  • Increased awareness and diagnostic vigilance for Marjolin ulcer are essential.
  • Timely diagnosis and appropriate treatment can improve prognosis.
  • Understanding the pathogenesis may lead to novel therapeutic strategies.