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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

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create: a software to create input files from diploid genotypic data for 52 genetic software programs.

J A Coombs¹, B H Letcher, K H Nislow

¹Program in Organismic and Evolutionary Biology, University of Massachusetts, Amherst, MA 01003, USA, S.O. Conte Anadromous Fish Research Center, US Geological Survey/Leetown Science Center, One Migratory Way, Turners Falls, MA 01376, USA, Northern Experimental Research Station, US Forest Service, 201 Holdsworth Hall, University of Massachusetts, Amherst, MA 01003, USA.

Molecular Ecology Resources

|May 19, 2011

Summary

This summary is machine-generated.

This software simplifies genetic data management for 52 analysis programs. It converts various file types, aiding in tasks like parentage assignment and sibship reconstruction.

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Area of Science:

Population Genetics
Bioinformatics
Computational Biology

Background:

Genetic data analysis requires specialized input files for diverse software.
Manual data conversion is time-consuming and prone to errors.
Existing tools may lack flexibility in handling various data sources.

Purpose of the Study:

To introduce 'create', a Windows program designed for genetic data input file creation and conversion.
To support 52 different genetic data analysis software programs.
To streamline data preparation for population genetics and related fields.

Main Methods:

The 'create' program accepts data from text, Microsoft Excel, and Access files.
Users can specify columns for individual/population identifiers, demographic data, and genotypic information.
Source data requires one individual per row with contiguous genotypic data.

Main Results:

Successfully creates and converts input files for 52 genetic analysis programs.
Supports data organization for sibship reconstruction, parentage assignment, and general genetic analysis.
Offers user-defined mapping of source data columns to program requirements.

Conclusions:

'create' provides a flexible and efficient solution for preparing genetic data.
The software reduces the burden of data formatting for researchers.
Facilitates broader application of genetic analysis tools through simplified data input.