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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: Jun 1, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

[On frailty as a geriatric concept].

Pascal David1, Armelle Gentric

  • 1Équipe de recherche EPS JE 2535, Université de Bretagne Occidentale, Université de Bretagne Occidentale, Brest. Pascal.David@univ-brest.fr

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|May 19, 2011
PubMed
Summary

Frailty, a geriatric concept, is often seen as a path to death. However, the French term "fragilité" differs, suggesting frailty might be a fundamental aspect of the human condition.

Area of Science:

  • Gerontology
  • Philosophy of Medicine

Context:

  • The concept of frailty in geriatrics is traditionally viewed as a precursor to mortality.
  • The French term 'fragilité' may be a mistranslation and distinct from the English concept.

Purpose:

  • To differentiate the geriatric concept of frailty from the French term 'fragilité'.
  • To re-evaluate frailty as an inherent aspect of the human condition.

Summary:

  • Frailty, a key geriatric syndrome, is often associated with a decline towards death.
  • The French word 'fragilité' is distinct from and likely a mistranslation of the English term 'frailty'.
  • This distinction suggests that frailty may represent a fundamental component of the human experience.

Impact:

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

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Last Updated: Jun 1, 2026

Frailty Assessment in an Aging Mouse Model
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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

  • Challenges the unidirectional, negative trajectory associated with geriatric frailty.
  • Promotes a broader understanding of frailty beyond a purely clinical geriatric syndrome.
  • Encourages philosophical and existential considerations of frailty in human life.