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Transgenic Organisms

Transgenic Organisms

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Updated: Jun 1, 2026

The Zebrafish Tol2 System: A Modular and Flexible Gateway-Based Transgenesis Approach

The Zebrafish Tol2 System: A Modular and Flexible Gateway-Based Transgenesis Approach

Published on: November 30, 2022

[Progress in transgenic fish techniques and application].

Xing Ye¹, Yuan-Yuan Tian, Feng-Ying Gao

¹Pearl River Fishery Research Institute, Chinese academy of fisheries sciences, Guangzhou 510380, China. gzyexing@163.com

Yi Chuan = Hereditas

|May 19, 2011

Summary

Transgenic fish offer faster growth for aquaculture, but ecological risks require careful assessment. Research focuses on improving gene transfer efficiency and ensuring food safety for commercial application.

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Area of Science:

Genetics and Biotechnology
Aquaculture
Environmental Science

Context:

Transgenic techniques are revolutionizing fish breeding, with stable lines of growth hormone (GH) and fluorescence protein gene transfer established in various fish species.
The fast-growth trait in GH gene transgenic fish holds significant potential for enhancing aquaculture productivity and economic returns.

Purpose:

This paper reviews advancements in transgenic fish research, focusing on gene transfer methods and ecological impact assessments.
The goal is to provide a comprehensive overview of the current state and future directions in the field of transgenic fish development and application.

Summary:

Microinjection remains a common gene transfer method, though often leading to multi-site, multi-copy integrations. Co-injection with transposons or meganucleases enhances gene transfer efficiency.
Consideration of 'all fish' or 'auto genes' is proposed to address food safety concerns and optimize transgene expression.
Ecological risk assessment is a major hurdle for commercial transgenic fish application, with laboratory findings on fitness potentially not reflecting complex natural interactions.

Impact:

Transgenic fish present opportunities for improved aquaculture but necessitate rigorous evaluation of environmental risks.
Developing reliable ecological assessment methods in naturalized environments and implementing effective containment strategies are crucial for the safe commercialization of transgenic fish technology.