Related Experiment Video
Updated: Jun 1, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
Published on: March 15, 2024
Living donor exchange programs: theory and practice
1Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. rmonty@jhmi.edu
Background:
The crisis in organ availability has triggered innovative approaches to meet a rapidly expanding worldwide demand for donor kidneys. HLA and ABO incompatibility represents one of the most significant barriers to optimizing the utilization of living donors. Kidney paired donation (KPD) allows patients with incompatible live donors to receive compatible or better-matched organs by exchanging donors.
Sources Of Data:
The data presented in this review have been published and represent the most up-to-date sources of the theory and practice of KPD.
Areas Of Agreement:
There is wide agreement that in most cases the best transplant solution for a patient with an incompatible donor is to receive a compatible organ in a KPD.
Areas Of Controversy:
There has been disagreement about the capacity of KPD to solve the incompatibility problem. However, it is now clear that not all phenotypes will benefit from KPD.
Growing Points:
Combining KPD with desensitization greatly expands the boundaries of each of these modalities.
Related Concept Videos
Kidney Transplant I: Introduction
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant II: Surgical Procedure
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

