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Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

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Childhood leprosy: lest we forget.

Sandeep Sachdeva1, Syed Suhail Amin, Zulfia Khan

  • 1Department of Community Medicine, JN Medical College, Aligarh Muslim University, Durgabadi Marris Road, Aligarh, Uttar Pradesh 202002, India. sandeepsemail@rediffmail.com

Tropical Doctor
|May 19, 2011
PubMed
Summary

Childhood leprosy in India presents a significant social challenge, indicating potential gaps in elimination programs. Early detection and prophylactic measures are crucial for managing pediatric leprosy cases effectively.

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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)
09:39

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

Published on: July 15, 2011

Area of Science:

  • Public Health
  • Epidemiology
  • Pediatrics

Background:

  • Leprosy remains a critical public health and social concern in South Asia, especially India.
  • Childhood leprosy contributes to a substantial social burden due to disabilities and misconceptions about transmission and treatment.
  • The incidence of leprosy in children may signal deficiencies in national leprosy elimination strategies.

Purpose of the Study:

  • To report a decade-long retrospective study on childhood leprosy.
  • To analyze socio-epidemiologic factors associated with pediatric leprosy.
  • To highlight the need for early detection and prophylaxis in children.

Main Methods:

  • Retrospective analysis of childhood leprosy cases.
  • Study conducted in a tertiary care hospital setting.
  • Data collected over a 10-year period (2000-2009).

Main Results:

  • The study analyzed childhood leprosy cases over a 10-year period.
  • Socio-epidemiologic correlates of pediatric leprosy were examined.
  • Findings underscore the persistence of leprosy in children.

Conclusions:

  • Early detection of leprosy in children is paramount.
  • Prophylactic measures should be implemented for susceptible children.
  • Addressing childhood leprosy is vital for national elimination goals.