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Diffusion tensor imaging of prostate at 3.0 Tesla.

Chunmei Li¹, Min Chen, Saying Li

¹Department of Radiology, Beijing Hospital, China.

Acta Radiologica (Stockholm, Sweden : 1987)

|May 19, 2011

Summary

Diffusion tensor imaging (DTI) shows promise for diagnosing prostate cancer. This study found significant differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values between cancerous and non-cancerous prostate tissues.

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Area of Science:

Radiology
Medical Imaging
Oncology

Background:

Diffusion Tensor Imaging (DTI) feasibility in prostate studies is established.
Apparent Diffusion Coefficient (ADC) and Fractional Anisotropy (FA) values in healthy and pathological prostates are debated.

Purpose of the Study:

To assess 3.0 T DTI efficacy for diagnosing prostate cancer in the peripheral zone.
To establish normative ADC and FA values for the healthy prostate.

Main Methods:

3.0 T MRI with T2-weighted imaging (T2WI) and DTI performed on 33 biopsy-confirmed prostate cases.
Comparison of ADC and FA values between cancerous and non-cancerous sextants.
ROC curve analysis to evaluate diagnostic performance of ADC, FA, and combined values.
Acquisition of DTI data from 20 healthy volunteers for normative value determination.

Main Results:

Normal central gland showed lower ADC and higher FA than the peripheral zone (P < 0.0001).
Significant differences in ADC and FA values were observed between cancerous and non-cancerous sextants (P < 0.0001).
Combined DTI and FA values demonstrated superior diagnostic ability compared to FA alone (AUC 0.86 vs. 0.76, P = 0.0009).

Conclusions:

Prostate ADC and FA values correlate with microstructural organization.
DTI is a potential tool for diagnosing peripheral zone prostate cancer.