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Updated: Jun 1, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Quantitative enhancement washout analysis of solid cortical renal masses using multidetector computed tomography
Haytham M Shebel1, Khaled M Elsayes, Khaled Zaky Sheir
1Department of Radiology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Quantitative enhancement washout using multidetector computed tomography aids in differentiating benign from malignant solid renal masses. This method shows promise for preoperative diagnosis of various kidney tumor subtypes.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Solid renal masses require accurate preoperative differentiation between benign and malignant subtypes.
- Multidetector computed tomography (MDCT) offers multiphasic imaging capabilities for renal mass characterization.
Purpose of the Study:
- To prospectively evaluate the utility of quantitative enhancement washout on MDCT for distinguishing benign solid renal masses from malignant subtypes.
- To assess the diagnostic performance of enhancement patterns in differentiating renal tumors.
Main Methods:
- A prospective study involving 97 patients with solid renal masses undergoing multiphasic MDCT (unenhanced, arterial, parenchymal, delayed phases).
- Analysis of maximum attenuation values, enhancement (ΔH), and washout in parenchymal and delayed phases.
- Statistical comparison using Kruskal-Wallis and Mann-Whitney U tests.
Main Results:
- Clear cell renal cell carcinoma (CCRCC) showed highest arterial enhancement and parenchymal phase washout.
- Chromophobe renal cell carcinomas exhibited the second highest parenchymal washout.
- Malignant lesions (except PRCC) demonstrated higher delayed phase washout than benign lesions.
Conclusions:
- Multiphasic MDCT with quantitative enhancement washout analysis can aid in the preoperative differentiation of solid renal masses.
- Arterial-phase attenuation and washout patterns are valuable imaging biomarkers for characterizing renal tumors.
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