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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 1, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Metastatic basal cell carcinoma.

Yalcin Alimoglu¹, Erkan Kilic, Hasan Mercan

¹Department of Otorhinolaryngology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. alimoglu2001@gmail.com

The Journal of Craniofacial Surgery

|May 19, 2011

Summary

Basal cell carcinoma (BCC), a common skin cancer, rarely metastasizes. This case highlights a patient with aggressive, recurrent BCC developing widespread skeletal and liver metastases after multiple surgeries.

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Last Updated: Jun 1, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Oncology
Dermatology
Medical Research

Background:

Basal cell carcinoma (BCC) is the most prevalent form of skin cancer.
BCC typically exhibits a high rate of local recurrence but rarely metastasizes.

Observation:

A 65-year-old male presented with a history of recurrent BCC on the medial canthus of the left eye.
The patient underwent approximately 12 surgical procedures over 10 years for local recurrences.
Three years post-final surgery, a suspicious lesion and lumbar pain were noted.

Findings:

Radiological imaging revealed extensive skeletal and liver metastases.
The patient was referred for oncology treatment, including radiation therapy and chemotherapy.

Implications:

This case underscores the rare but severe potential for BCC metastasis.
Highlights the importance of vigilant monitoring for distant spread in aggressive or recurrent BCC cases.
Suggests a need for further research into the mechanisms of BCC metastasis and optimal management strategies.