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Updated: Jun 1, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Diffuse large B-cell lymphoma with oral manifestations.

Emel Bulut¹, Burak Bekçioğlu, Omer Günhan

¹Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey.

The Journal of Craniofacial Surgery

|May 19, 2011

Summary

Diffuse large B-cell lymphoma (DLBCL), a common non-Hodgkin lymphoma (NHL), can manifest in various sites. This report details a case of DLBCL presenting as mandibular pain and edema, confirmed by biopsy.

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Last Updated: Jun 1, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Hematology
Oncology
Oral Pathology

Background:

Non-Hodgkin lymphomas (NHLs) are diverse lymphoproliferative disorders with variable prognoses.
Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of NHL in adults, constituting approximately 30% of cases.
DLBCL is characterized by clinical, morphological, and genetic heterogeneity, arising from mature B cells.

Observation:

A 64-year-old male presented with localized mandibular pain and edema.
The patient's symptoms indicated a potential extranodal manifestation of lymphoma.
Clinical and histopathological evaluation was performed to diagnose the condition.

Findings:

Excisional biopsy of the affected mandibular premolar region revealed diffuse large B-cell lymphoma.
The findings confirm DLBCL as the cause of the patient's symptoms.
This case highlights an unusual extranodal presentation of DLBCL.

Implications:

Early recognition of extranodal DLBCL is crucial for timely diagnosis and treatment.
Mandibular presentations of lymphoma require thorough histopathological investigation.
Understanding DLBCL heterogeneity aids in tailoring treatment strategies for improved patient outcomes.