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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N-[(E)-2,4-Dichloro-benzyl-idene]-4-methyl-aniline
This study details the crystal structure of a compound containing 4-methyl-anilinic and 2,4-dichloro-benzaldehyde groups. The analysis reveals specific dihedral angles and intermolecular interactions influencing crystal packing.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure
Background:
- Understanding molecular conformation and crystal packing is crucial in materials science and drug design.
- The specific arrangement of functional groups dictates a compound's physical and chemical properties.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(14)H(11)Cl(2)N.
- To analyze the dihedral angle between key molecular moieties.
- To investigate intermolecular interactions governing crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and dihedral angles.
- Identification and analysis of non-covalent interactions, specifically C-H⋯π interactions.
Main Results:
- The dihedral angle between the 4-methyl-anilinic and 2,4-dichloro-benzaldehyde moieties was determined to be 7.37(8)°.
- C-H⋯π interactions involving the methyl group and the anilinic ring were identified.
- These interactions play a significant role in stabilizing the crystal lattice.
Conclusions:
- The study provides precise structural data for the title compound.
- The identified C-H⋯π interactions are key to understanding the observed crystal packing.
- This structural insight can inform the design of related molecules with tailored properties.
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